Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC LM11A-31 dihydrochloride | 1243259-19-9 | 99.9% | 316.27 | 1 ML
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LM11A-31 dihydrochloride is a non-peptide modulator of p75NTR (neurotrophin receptor p75) and an orally active, potent antagonist of proNGF (nerve growth factor). This amino acid derivative demonstrates high blood-brain barrier permeability, effectively blocking p75-mediated cell death. It has been shown to reverse cholinergic neurite dystrophy in mouse models of Alzheimer's disease at mid- to late-stage progression.
- Non-peptide p75NTR modulator
- Orally active and potent proNGF antagonist
- Amino acid derivative
- High blood-brain barrier permeability
- Blocks p75-mediated cell death
- Reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models
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Medchemexpress LLC 7,4'-Dihydroxyflavone | 2196-14-7 | 25 MG
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7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis. It functions as an eotaxin/CCL11 inhibitor and a CBR1 inhibitor with an IC50 of 0.28 μM. This compound suppresses eotaxin production and prevents dexamethasone (Dex)-paradoxical adverse effects. Furthermore, 7,4'-DHF inhibits MUC5AC gene expression, mucus production, and secretion by regulating NF-κB, STAT6, and HDAC2, decreasing PMA-stimulated MUC5AC expression in NCI-H292 human airway epithelial cells with an IC50 of 1.4 μM.
- Purity: 99.64%
- Molecular weight: 254.24
- Formula: C15H10O4
- CAS number: 2196-14-7
- Appearance: Solid, light yellow to yellow
- Structure classification: Flavonoids, Flavones, Phenols, Polyphenols
- Acts as eotaxin/CCL11 and CBR1 inhibitor (IC50: 0.28 μM)
- Inhibits MUC5AC gene expression and mucus production
- IC50: 1.4 μM (NCI-H292 human airway epithelial cell)
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Ambeed R 5 S 1 2Dihydroxyethyl 3 4d
(R)-5-((S)-1,2-Dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one, 50-81-7, 98%
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Ambeed 3 2 9HFluoren9yl methoxy ca
3-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethoxy)propanoic acid, 1654740-73-4, 97%
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Apexbio Technology LLC Ro 31-8220 125314-64-9 50mg
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Ro 31-8220 (CAS 125314-64-9) is a potent and selective inhibitor of protein kinase C (PKC) targeting isoforms PKC- (IC50 5 nM) PKC- I (24 nM) PKC- II (14 nM) PKC- (27 nM) and PKC- (24 nM) PKC is a Ca2 and phospholipid-dependent serine/threonine kinase involved in signaling pathways regulating cell proliferation and malignancy Ro 31-8220 modulates downstream signaling by inducing c-Jun expression and activating JNK1 while inhibiting MKP-1 and c-Fos expression independent of PKC activity In immunological studies it suppresses IL-2 production (IC50 80 nM) T cell proliferation (IC50 350 nM) and CD25 expression indicating inhibition of both early and late T cell activation Ro 31-8220 is widely utilized in cellular and molecular studies to dissect PKC-dependent and independent signaling mechanisms
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Medchemexpress LLC 2-Octyl-4(1H)-quinolone | 80554-60-5 | >=98.0% | 257.37 | 50 MG
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2-Octyl-4(1H)-quinolone is a quinolinone alkaloid that can be isolated from *Ruta graveolens*. It is intended for research use only. It has shown antiproliferative activity against human A2780 cells with an IC50 of 12 μM after 2 days by Alamar blue assay. The compound is a solid, white to off-white in color, with the formula C17H23NO. It is classified under Alkaloids and Other Alkaloids, and its initial source is from the plants Rutaceae, specifically *Ruta graveolens Linn.*.
- Quinolone alkaloid.
- Isolated from *Ruta graveolens*.
- For research use only.
- Exhibits antiproliferative activity against human A2780 cells with an IC50 of 12 μM after 2 days by Alamar blue assay.
- Solid, white to off-white in color.
- Chemical formula C17H23NO.
- Classified under alkaloids.
- Sourced from Rutaceae, *Ruta graveolens Linn.*.
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Ambeed 2 4Bromophenyl isoindoline1 3d
2-(4-Bromophenyl)isoindoline-1,3-dione, 40101-31-3, 98%
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Apexbio Technology LLC Batimastat (BB-94)(Synonyms: BB-94, Batimastat, MMP inhibitor BB-94), 25mg, CAS: 130370-60-4.
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Batimastat (BB-94 CAS 130370-60-4) is a synthetic small-molecule inhibitor targeting matrix metalloproteinases (MMPs) Structurally a polypeptide-like analogue of collagen substrates batimastat contains a peptidic backbone and a hydroxamate moiety that binds the catalytic zinc atom of MMPs It inhibits several MMP subtypes markedly including MMP-1 MMP-2 MMP-3 MMP-7 and MMP-9 with reported IC50 values of 3 4 20 6 and 4 nM respectively In preclinical studies batimastat demonstrates inhibitory effects on tumor growth and angiogenesis across various tumor models including ovarian and colon carcinoma xenografts making it relevant for cancer research and therapeutic development
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Chemscene ChemScene | Acridone | 100G | CS-W007771 | 0.98 | 578-95-0| MFCD00005019 | 195.22
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ChemScene | Acridone | 100G | CS-W007771 | 0.98 | 578-95-0| MFCD00005019 | 195.22
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Ambeed S 3 4 2Chloro5iodobenzyl phen
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran, 915095-94-2, 97%
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Medchemexpress LLC Pomalidomide-amido-C3-COOH | 2162120-77-4 | 99.5% | 387.34 | 100 MG
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Pomalidomide-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Pomalidomide-based cereblon ligand
- Linker used in PROTAC technology
- Intended for research use only
- Solid appearance
- White to light yellow color
- Stable under recommended storage conditions
- Used in cancer and cancer targeted therapy research
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Medchemexpress LLC Dextran T7 (MW 7,000) | 9004-54-0 | 5600-8400 | 10 G
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Dextran T7 (Dextran 7; Dextran D7) (MW 7,000) is a polymer of anhydroglucose with an average molecular weight of 7000. It exhibits good biodegradability and biocompatibility, making it suitable for use in food, pharmaceutics, cosmetics, and research.
- Used as an encapsulation material for superparamagnetic magnetite nanoparticles, which can be formulated into a liver contrast agent for magnetic resonance imaging.
- Can be conjugated with cytosine deaminase (CDA) from Aspergillus niger to enhance the enzyme's structural stability, resistance to protease degradation, and anti-proliferative activity.
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Medchemexpress LLC 31-Norlanostenol | 16910-39-7 | 1 MG
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31-Norlanostenol is a triterpenic compound isolated from the latex of Euphorbia officinarum. It can act as an efficient insect growth regulator on S. frugiperda and Tenebrio molitor. This product is for research use only.
- Triterpenic compound
- Isolated from the latex of Euphorbia officinarum
- Acts as an efficient insect growth regulator on S. frugiperda and Tenebrio molitor
- Purity: 99.94%
- Molecular Weight: 414.71
- Formula: C29H50O
- Appearance: Solid
- Color: White to off-white
- Structure classification: Terpenoids, Triterpenes
- Initial source: Plants, Euphorbiaceae, Euphorbia boetica
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Medchemexpress LLC Leb-03-146 | 2858812-91-4 | 98.1% | C46H57N11O8 | 1 MG
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LEB-03-146 is a deubiquitinase-targeting chimera (DUBTAC) that links AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 via a PEG2 linker. This compound is intended for research use only.
- Demonstrates significant WEE1 stabilization in HEP3B hepatoma cancer cells.
- Functions as a deubiquitinase-targeting chimera (DUBTAC).
- Links AZD1775 (Adavosertib) to the OTUB1 recruiter EN523.
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Apexbio Technology LLC 4-quinolinol 611-36-9 500mg
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4-Quinolinol (CAS 611-36-9) is a hydroxylated derivative of quinoline with demonstrated antimicrobial properties It exerts inhibitory effects on the growth of various intestinal bacteria suggesting interference with microbial viability or metabolic pathways Additionally 4-quinolinol has been utilized in research as a sacrificial scavenger for photogenerated reactive oxygen species supporting studies on oxidative stress and photochemical processes These features highlight its utility in microbiological research and investigations into oxidative mechanisms
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